All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Valproate formulation and rescue sedation: what PRN medication counts actually measure
A retrospective study linked valproate formulation with combined rescue antipsychotic or benzodiazepine use, but the outcome was a prescribing proxy rather than a direct agitation score.
A Cannabinoid Agonist Enhanced Levetiracetam but Not Clobazam in a Mouse Seizure Test
A preclinical interaction study found a selective positive result that did not extend to clobazam.
Benzodiazepines and Propofol Appeared on Both Sides of a Refractory-Seizure Case Narrative
A perioperative case attributed status epilepticus to propofol even though later control involved propofol and diazepam together.
Naloxone Dispensing Surveillance Used Benzodiazepine Co-Use as Risk Context, Not a Reversal Target
A U.S. pharmacy report examined naloxone access and discussed concurrent benzodiazepine use within opioid overdose-risk assessment.
Ophthalmic Emergence-Agitation Meta-Analysis Included Midazolam but Rankings Were Indirect
A network meta-analysis associated adjunct midazolam with less emergence agitation than placebo in pediatric ophthalmic surgery.
Hypoactive Delirium Was Often Missed in an ICU Cohort That Also Examined Benzodiazepines
A medical ICU study found many delirium cases were hypoactive, making visible agitation an incomplete indicator.
Benzodiazepines in Akathisia Case Management: Restlessness Was Not Simply Anxiety
Two case reports describe akathisia during complex drug regimens and use of several symptom-directed treatments.
Diabetes and Midazolam Metabolism: The Supplied Paper Was a Study Protocol
A pharmacokinetic protocol proposed using midazolam as one probe of drug metabolism before and after glycemic control.
Benzodiazepine Variety Predicted Diagnostic Conversion in a Model, Not a Drug-Caused Bipolar Disorder
A claims-based prediction study included benzodiazepine prescribing patterns among variables associated with later bipolar diagnosis.
Benzodiazepines and Orthostatic Hypotension in Older Adults: A Small Study Had Wide Intervals
A primary-care study associated benzodiazepine use with orthostatic hypotension in adults aged at least 80, with substantial uncertainty.
Midazolam Was Incompatible With Tested Plasma-Lyte Admixtures
A laboratory study found physical incompatibility and later concentration instability when midazolam was mixed with two Plasma-Lyte formulations.
Benzodiazepines as Possible Contributors in a Clozapine Hypothermia Case
A hypothermia report considered several drugs and diseases rather than establishing a single definitive cause.
Clonazepam in Stiff-Limb Syndrome: Improvement Followed Several Treatments
A rare movement-disorder case described clinical improvement during combined symptomatic and immune-directed treatment.
Neonatal Injury With Multiple Prenatal Exposures: Benzodiazepine Attribution Was Unresolved
A neonatal case report described severe abnormalities after several reported maternal exposures, without isolating a benzodiazepine effect.
Two Urine Benzodiazepine Screens Had Different Sensitivities Against Serum Analysis
A prospective poisoning study found that the choice of urine screening kit affected benzodiazepine detection performance.
Long-Acting Benzodiazepines in a Swedish Hospitalization Study: The Combined Risk Flag Lost Significance
A case-control study found that a potentially inappropriate medication category was not independently associated with hospitalization in its full model.
Insomnia With Diabetes or Hypertension: A Review Does Not Prove One Hypnotic Improves Disease Control
A narrative review discusses insomnia treatment in people with cardiometabolic comorbidity, including benzodiazepines and alternatives.
Pearl Powder and Estazolam in Rats: Protein Differences Did Not Establish Clinical Superiority
A sleep-deprivation experiment compared behavioral and hippocampal protein changes after pearl powder and estazolam.
Flumazenil Blocked Dieckol’s Mouse Sleep Effect: A Mechanistic Clue With Limits
A mouse study used an antagonist to investigate how a marine polyphenol affected non-REM sleep.
Clobazam in Pediatric Polytherapy: A Common Add-On Was Not Assigned Every Reported Adverse Effect
A pediatric epilepsy study found frequent reported adverse effects in a population where clobazam was a common add-on medicine.
Cerebral Malaria Seizure Trial: Benzodiazepine Rescue Changed the Comparator Pathway
A small pediatric trial changed when phenobarbital was given, making its efficacy comparison conditional on the revised treatment sequence.
Clonazepam Plus Levetiracetam in Isolated Arm Apraxia: A Seizure Case Needed Electrical Evidence
A patient with sudden right-arm apraxia improved after combined antiseizure treatment, alongside a change in focal EEG activity.
Alcohol Withdrawal and Myocardial Injury: Benzodiazepine Timing Was Part of a Complex Case
A case report describes a coronary event during evolving withdrawal, with benzodiazepine treatment occurring within a wider clinical course.
Cannabidiol and Clobazam: An Epilepsy Review Separates Interaction From Independent Benefit
A cannabinoid review describes clobazam interaction as a possible contributor to both somnolence and apparent treatment benefit.
Insomnia Education Added to Lorazepam: A Small Study Tested a Combined Approach
A nonrandomized primary-care study associated brief education with better sleep scores when both groups initially received lorazepam.
Majorcan Insomnia Survey: Common Benzodiazepine Treatment Did Not Establish Symptom Control
A primary-care survey described insomnia, comorbidity, and treatment use, rather than testing whether benzodiazepines worked.
Midazolam in a Three-Drug Rat Anesthetic: Route Changed Duration and Respiratory Findings
A rat experiment found different anesthetic effects by injection route for a medetomidine-midazolam-butorphanol mixture.
Midazolam and Endoscopy Discomfort: Patient and Operator Factors Also Mattered
A cross-sectional endoscopy study associated sedation with less discomfort while also identifying patient and endoscopist differences.
Emergence Agitation and Benzodiazepines: The Outcome Definition Shapes the Association
A postoperative observational study linked benzodiazepine premedication with an agitation-based outcome, leaving causal and diagnostic uncertainty.
Chronic Benzodiazepine Claims as a Quality Measure: A Flag Is Not an Individual Verdict
A medication-quality framework counted chronic benzodiazepine use as a safety signal while acknowledging that clinical circumstances can justify it.