All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Did 5 mg/kg of Caffeine Slow Soccer Players’ Thinking? A 12-Player Crossover Trial
In 12 male soccer players, 5 mg/kg caffeine selectively slowed Stroop responses while small-sided games generally shortened responses. Original evidence and forensic limitations.
Why Did 3 mg/kg Caffeine Change Stroop Speed and Prefrontal fNIRS Signals When 9 mg/kg Did Not? A 10-Man Crossover Trial
A 10-man caffeine crossover found 3 mg/kg improved Stroop speed and congruent-task prefrontal fNIRS HbO, while 9 mg/kg and accuracy showed no significant dose benefit. No blood caffeine was assayed.
Does Lisdexamfetamine Improve Attention More Than Guanfacine? A 22-Participant Crossover Study
A 22-participant randomized crossover found faster, steadier lab responses with lisdexamfetamine, while guanfacine worsened variability. Read true nulls and limits.
Does Loss of TAAR1 Heighten Methamphetamine Reward but Not Morphine Reward? Evidence From Mouse Conditioning
Primary mouse research: TAAR1 deletion raised stimulant locomotion and altered methamphetamine place-preference acquisition and extinction, but not all outcomes were significant.
Does Lisdexamfetamine Improve Sleep or Cause Insomnia in Adult ADHD? What a 420-Person Trial Found
In 420 adults, LDX improved PSQI daytime dysfunction but not overall sleep quality. Insomnia reports were 19.3% vs 4.8% placebo. Full evidence limits.
Can Atomoxetine Reduce Dextroamphetamine’s Effects? What a 10-Person Crossover Actually Measured
What ten healthy volunteers showed about atomoxetine pretreatment, oral d-amphetamine, blood pressure, subjective ratings and plasma cortisol—and what was not measured.
Does Intranasal Methamphetamine Improve a Feeling of Control Without Improving Every Task? A 10-Person Study
A blinded 10-person intranasal methamphetamine study found 12-mg agency and hit-rate benefits but 25/50-mg conditional errors, genuine nulls and no forensic blood cutoff.
Can Serum Methamphetamine Predict Alertness and Simulator Errors? A 16-Person Narcolepsy Trial
A source-based review of oral methamphetamine, measured serum drug concentrations, MSLT alertness and computerized obstacle errors in 16 adults. No individual DUI threshold.
Does Theta-Burst Stimulation Change Methamphetamine-Word Attention? A 49-Person EEG Trial
A 49-person sham-controlled trial tested 20 sessions of iTBS, methamphetamine-word Stroop errors, N1/P3 EEG and beta power. Learn what significant and null results permit—and what blood toxicology it never measured.
Does 9 mg/kg Caffeine Improve Attention More Than 3 mg/kg? A 14-Athlete Crossover Trial
Original four-dose crossover: 3 and 6 mg/kg caffeine shortened reaction times in 14 young female athletes; 9 mg/kg was not better than placebo and drew more symptom reports. No blood caffeine measured.
Can Immersed Hair Reference Materials Make Forensic Drug Results More Consistent? An Eight-Laboratory Study
Original forensic study: eight laboratories showed smaller hair drug-test CVs with immersed matrix reference materials. Understand washing, homogeneity and limits.
Why Did Methylphenidate’s Delayed-Recall Advantage Lose Significance After Depression-Symptom Adjustment? An 18-Adult ADHD Crossover
Original n18 adult ADHD crossover: delayed word recall improved before CES-D adjustment, lost statistical significance afterward. Genuine nulls and forensic limits.
Can Genetic Testing Predict Whether Caffeine Prevents Attention Lapses? A 37-Person Sleep-Loss Trial
Can TNF, COMT, PER3 or ADORA2A variants predict caffeine vigilance benefits? Explore a 37-person crossover trial, true null findings and forensic limits.
Can Brain MRI Establish Methamphetamine-Related Cognitive Impairment? What an 88-Man Structural Study Found
An 88-man original MRI study found four adjusted cognitive differences but six null results. Brain cortical thickness is not a methamphetamine blood or DUI test.
Can a Sweat Patch Detect Cocaethylene Alongside Cocaine? What 21 GC–MS Patch Results Actually Show
An original 21-patch, 11-person GC–MS study detected cocaine and cocaethylene in sweat. Learn what 12.5 ng/patch detects—and cannot prove about dose, alcohol, or impairment.
Does Switching From Amphetamine to Lisdexamfetamine Improve Adult ADHD? Why Two Placebo Patients Limit the Evidence
An original 41-adult ADHD subgroup had just two placebo patients. See what lisdexamfetamine symptom changes show—and what blood testing was absent.
Can Oral Methamphetamine Mask Low-Dose Alcohol’s Cognitive Effects? A 16-Adult Crossover Trial
In 16 adults, oral methamphetamine altered some low-dose alcohol cognition and sleepiness tests. Oral fluid and breath were measured—not blood impairment.
Does Methamphetamine Abstinence Change Brain Responses to Drug and Sexual Cues? A 20-Person fMRI Study
In 20 abstinent methamphetamine patients rescanned, sexual-picture fMRI contrasts differed late in abstinence, but between-session recovery was unclear. Examine the data and forensic limits.
Does Lisdexamfetamine Show Rewarding and Reinforcing Effects in Rodents? What Three Laboratory Tests Actually Establish
Yun et al. tested mouse conditioned place preference, rat IV self-administration and isolated synaptosome dopamine. Learn actual N, dose limits and why this is not human blood impairment evidence.
Can Lisdexamfetamine Reduce Cocaine Craving Without Lowering Positive Urine Tests? A 43-Person Trial
A 43-person lisdexamfetamine trial lowered self-reported cocaine craving but did not significantly reduce urine benzoylecgonine positivity in all randomized patients.
Can Lisdexamfetamine Improve Attention After Childhood Concussion? What a 16-Child Crossover Trial Measured
A 16-child randomized lisdexamfetamine crossover trial after traumatic brain injury: attention findings, conflicting CPT statistics, null scales, anxiety and absent blood assays.
Can a Rat Plasma Amphetamine Level Predict Attention or Impairment? What Eleven Rats Actually Showed
Rat plasma d-amphetamine at roughly 44–102 ng/mL aligned with attention gains in a separate behavioral group—not a human whole-blood impairment cutoff.
Did 30, 50, and 70 mg Lisdexamfetamine Help 76 Japanese Children With ADHD? What the Trial—and Its Safety Data—Show
Original trial analysis: 76 Japanese children with ADHD, three lisdexamfetamine target doses, an early null result, adverse events and forensic limits.
Does Lisdexamfetamine Help Adults With ADHD Quit Smoking? A 32-Person Nicotine-Patch Trial
In a 32-adult randomized trial, lisdexamfetamine improved ADHD ratings but not CO-verified smoking abstinence versus nicotine patches and placebo. Source data and limits.
Can a Positive Forehead Cocaine Swab Prove Cocaine Use? A 158-Person Hair Comparison
Original study: 19/158 cocaine forehead swabs vs 10/158 hair positive; skin contact can persist, so a swab cannot prove ingestion, impairment or use time.
Does Lisdexamfetamine Improve Daily Life in Adults With ADHD? What 161 Randomized Patients Actually Reported
In 161 randomized adults, lisdexamfetamine improved six tested AIM-A domains; AAQoL differences were descriptive. No forensic drug blood levels or driver testing.
Does Lisdexamfetamine Produce a Lower Plasma Amphetamine Peak? A 24-Person Direct Comparison
A 24-person trial found delayed plasma amphetamine after lisdexamfetamine, but similar modeled peak, exposure and drug liking. Understand forensic limits.
Were Mixed Amphetamine Salts Noninferior to Modafinil for Sleepiness? A 44-Adult Trial
A 44-adult randomized study did not prove mixed amphetamine salts noninferior to modafinil on Epworth scores (p=.11), despite selected secondary results.
Can Smartphone Working-Memory Training Improve Self-Control During Methamphetamine Treatment? A 35-Patient Pilot
In 35 inpatient methamphetamine-treatment patients, smartphone n-back practice coincided with selected self-reported gains. Read real nulls and forensic limits.
Does Early Methamphetamine Abstinence Affect Trail Making Performance? A 79-Person Study of Speed, Errors, and Route of Use
A 79-person primary study found slower Trail Making performance in early methamphetamine abstinence, with complex-task errors, real nulls and forensic limits.