All Articles
Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
Perampanel Case Reported Seizure Cessation After a Regimen Including Midazolam Had Been Insufficient
A super-refractory status epilepticus case described improvement after adding perampanel. The treatment sequence was suggestive but did not isolate the new drug’s contribution.
Anise Mouse Study Used Bromazepam as an Anxiety Comparator While Testing Memory Separately
A plant-extract study reported anxiety-like effects without detected memory changes on its chosen tasks. A favorable comparison did not establish human cognitive safety.
CKD Delirium Cohort Reported a Benzodiazepine Subgroup Interaction in Its Statin Analysis
An observational ICU study associated statin exposure with less delirium. A subgroup interaction involving benzodiazepine use did not establish that statins counteracted benzodiazepine toxicity.
Headache Review Found Ketamine–Midazolam Aura Results Did Not Extend to Aura Duration
A systematic review described one trial favoring intranasal ketamine over midazolam for aura severity. The same trial did not show superiority for aura duration.
COVID Psychosis Case Review Described Benzodiazepine Use Without Isolating Its Treatment Effect
A systematic review collected reports of psychosis during the pandemic. Treatment and favorable outcomes were commonly described, but the case literature could not identify a benzodiazepine-specific benefit.
Diazepam Appeared as an Inflammatory-Bowel-Disease Repurposing Candidate in Linked Data Analyses
A computational study combined adverse-event reports, claims, and gene-expression patterns to identify potential uses of existing medicines. Candidate selection was not proof of clinical efficacy.
Essential-Oil Chemistry Study Identified New Benzodiazepine Structures Without Testing Sedative Effects
A synthesis paper converted a natural essential-oil constituent into several chemical products. Structural confirmation did not demonstrate that the products act like prescribed benzodiazepines.
Rifapentine Modeling Used Midazolam Interaction Data as a Check Before Predicting Another Drug Pair
A pharmacokinetic model used published midazolam interaction observations to assess a CYP3A-induction component. Its main predictions concerned rilpivirine, not a new midazolam clinical trial.
Calotropis Seizure Experiments Found Protection That Flumazenil Did Not Reverse in One Model
A plant-extract study used several induced-seizure paradigms. Its antagonist result did not support simply treating the extract as a benzodiazepine equivalent.
Mouse Development Study Found Different Diazepam-Sensitive Windows for Later Anxiety-Like and Swim Behavior
A developmental experiment linked the timing of transient diazepam exposure to different adult behavioral outcomes. The mouse age windows were not human clinical dosing guidance.
Preclinical Brain-Injury Review Separated GABAergic Sedation From Demonstrated Neuroprotection
A review found inconsistent or unfavorable recovery findings for GABAergic anesthetics in animal brain-injury experiments. Sedation and protection of injured brain tissue were separate endpoints.
Mouse Sleep Study Found Quercetin and Ascorbate Modified Diazepam-Related Effects in a Barbiturate Model
An experiment examined how quercetin and ascorbic acid changed drug-induced sleep in mice. Its behavioral and docking results did not establish a treatment for human benzodiazepine toxicity.
Korean Dental Claims Study Found Midazolam Was the Most Common Sedative Recorded for Dementia Care
A national claims analysis described sedation and general anesthesia during dental treatment in people with dementia. It counted care patterns rather than directly testing sedative safety.
Cancer–COVID Cohort Reported More Anticipatory Benzodiazepine Prescribing With Palliative-Team Involvement
A European cohort described care planning and symptom-control prescribing during the first pandemic wave. Anticipatory prescribing did not establish that every prescribed dose was administered.
Rhinoceros Study Found No Significant Tremor Reduction With Etorphine–Midazolam Immobilization
A veterinary field study tested whether a midazolam-containing regimen reduced muscle tremors. The measured tremor scores did not differ significantly from the comparison regimen.
Infant Startle–Apnea Case Reported Inadequate Clonazepam Response Before Improvement With Piracetam
A case described severe hyperekplexia-like and breath-holding episodes. Its treatment sequence showed that a clonazepam trial did not fully control this particular presentation.
End-of-Life Anesthesia Review Distinguished Benzodiazepine Sedation From a Goal of Complete Unconsciousness
A review discussed extending general anesthesia to refractory suffering at the end of life. It presented ethical and clinical arguments rather than a comparative outcomes trial.
Glaucoma Review Focused Benzodiazepine Concern on Angle Closure in Predisposed Eyes
A literature review discussed possible ocular adverse effects of psychotropic medicines. Its benzodiazepine section concerned angle-closure susceptibility rather than a uniform risk for every glaucoma type.
Diazepam Reduced Grooming Duration Without Restoring Its Pattern in a Shank3B Mouse Model
A behavioral study found that anxiety-like measures and repetitive grooming structure did not respond identically to diazepam. Total behavior time concealed differences in how the behavior was organized.
Mouse Epilepsy Model Separated Midazolam Rescue During Induction From Later Diazepam Treatment
A model-development study examined benzodiazepines at two different stages. Rescue after induced status epilepticus and treatment of later spontaneous seizures answered different questions.
Older-Age Bipolar Study Associated Current Benzodiazepine Use With Lower Cognitive Scores
A cross-sectional study found that benzodiazepine use was one of several factors associated with cognitive performance. It could not establish the direction or cause of that association.
Catatonia-Like Sedation Case Reported an Unrevealing Lorazepam Challenge Before Drug Revision
A psychiatric case described severe immobility during risperidone and valproate treatment. The authors considered medication-induced sedation after the presentation did not clarify with a lorazepam challenge.
Zebrafish Alkaloid Study Used Diazepam as a Comparator While Testing Serotonergic Involvement
An adult-zebrafish experiment found anxiety-like behavior changes with two plant-derived alkaloids. The diazepam control did not establish that the test compounds acted as benzodiazepines.
Amitriptyline Overdose Case Used Clonazepam for Myoclonus Within Complex Intensive Care
A severe antidepressant-poisoning report described serotonin-syndrome-like signs and later neuromuscular weakness. Clonazepam was one component of treatment rather than a tested antidote.
Bronchoscopy Trial Found No Added BIS Change With Remifentanil During Deep Midazolam-Based Sedation
A randomized ICU study tested additional remifentanil during bronchoscopy. A null difference in a processed EEG endpoint did not directly measure the absence of pain or awareness.
Infusion-Pump Case Used Manual Midazolam and Other Anesthetics After a Light-Anesthesia Warning
A case report linked a syringe-clamp problem to inadequate anesthetic delivery. A reassuring programmed infusion setting did not establish that the intended drug reached the patient.
Lafora Disease Case Replaced Broad Polypharmacy With a Regimen Including Clobazam
A Lafora disease report described improved seizure control and alertness after a stepwise medication revision. Removing medicines and adding others occurred within the same treatment course.
Border-City Syringe Residue Study Reported No Benzodiazepine Detections in Its Sample
A drug-residue study found fentanyl and stimulant mixtures but no benzodiazepines in the tested samples. That negative finding has a defined specimen and sampling context.
Emergency Department Loxapine Study Reported Less Benzodiazepine Rescue Use in a Selected Group
A retrospective agitation study associated inhaled loxapine with less rescue benzodiazepine use. Clinician selection of patients limits a causal comparison with injectable antipsychotic strategies.
European Pediatric Palliative Survey Described Midazolam Use and Clinicians’ Views on Sedation
A five-country survey found that midazolam was widely reported in pediatric palliative care. It measured practice reports and attitudes, without directly measuring survival effects.