EVIDENCE LIBRARY
Midazolam Was Incompatible With Tested Plasma-Lyte Admixtures
A laboratory study found physical incompatibility and later concentration instability when midazolam was mixed with two Plasma-Lyte formulations.
A laboratory study found physical incompatibility and later concentration instability when midazolam was mixed with two Plasma-Lyte formulations.
Different compatibility endpoints
The investigators assessed appearance, pH, and HPLC concentration at mixing, two hours, and 24 hours. Midazolam was physically incompatible with both Plasma-Lyte 148 and its glucose-containing formulation. It also failed the study’s chemical-stability criterion at two and 24 hours. Other tested drugs did not all behave the same way.
Admixture conditions control the inference
Compatibility depends on concentration, preparation, temperature, container, contact time, and formulation. A direct admixture experiment is not automatically a validation of every brief Y-site contact or another dilution. Stable pH also does not establish physical or chemical compatibility. The study supplies a concrete preparation concern, rather than evidence that a patient received a particular dose deficit. Assessing a clinical infusion requires the actual solution, mixing process, appearance, duration, and administration record.
Source paper
Original analysis of the supplied journal article, identified as PMC7311557.